舒红兵，北京大学生命科学学院长江学者特聘教授。聘任岗位：细胞生物学。研究方向：细胞信号转导。博士生导师。

　　个人简介

　　1987年获兰州大学理学学士学位；
　　1990年获中国医学科学院/中国协和医科大学理学硕士学位；
　　1995年获Emory大学（美国）博士学位；
　　1990-1992年，美国密西根大学研究助理；
　　1995-1997年，美国Tularik公司博士后；
　　1997-1998年，美国Magainin制药公司高级科学家；
　　1998-2003年，美国国家犹太医学及研究中心助理教授；
　　1999-2003年，美国科罗拉多大学健康科学中心助理教授；
　　2003-今， 美国国家犹太医学及研究中心副教授；
　　2003-今， 美国科罗拉多大学健康科学中心副教授；
　　1999－2004， 北京大学长江特聘教授

　　研究方向

　　1． 肿瘤坏死因子（TNF）家族成员信号转导
　　2． Toll样受体家族成员信号转导
　　3． 细胞凋亡

　　发表论文

　　1. Nabel, E.G., Shum, L., Pompili, V., Yang, Z., San, H., Shu, H.B., Lipty, S., Gordon, D., Derynck, R., and Nabel, G.J. (1993). Direct gene transfer of TGF-b into artery wall stimulate fibrocelllular hyperplasia. Proc. Natl. Acad. Sci. USA. 90, 10759-10763.
　　2. Shu, H.B., Agranoff, A., Nabel, E.G., Leung, K., Neish, A.S., Collins, and Nabel, G.J. (1993). Differential regulation of VCAM-1 gene expression by specific NF-kB subunits in endothelial and epithelial cells. Mol. Cell. Biol. 13, 6283-6289.
　　3. Shu, H.B., Li, Z., Palacios, M.J., Li, Q. and Joshi, H.C. (1995). A transient association of g-tubulin at the midbody is required for the completion of cytokinesis during the mammalian cell division. J. Cell Science 108, 2955-2962.
　　4. Shu, H.B. and Joshi, H.C. (1995). g-Tubulin can both neacleate microtubule assembly and self-assemble into tubular structures in mammalian cells. J. Cell Biol. 130, 1137-1147.
　　5. Rothe, M., Xiong, J., Shu, H.B., Williamson, K., Goddard, A. and Goeddel, D.V. (1996). I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. Proc. Natl. Acad. Sci. USA. 93, 8241-8246.
　　6. Hsu, H., Huang, J., Shu, H.B., Baichwal, V.R. and Goeddel, D.V. (1996). TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4, 387-396.
　　7. Hsu, H., Shu, H.B., Pan, M.G. and Goeddel, D.V. (1996). TRADD-TRAF2 and TRADD-FADD interactionss define two distinct TNF receptor-1 signal transduction pathways. Cell 84, 1-20.
　　8. Shu, H.B., Takeuchi, M. and Goeddel, D.V. (1996). The TNF receptor 2 signal transducers TRAF2 and c-IAP1 are components of the TNF receptor 1 signaling complex. Proc. Natl. Acad. Sci. USA. 93, 13973-13978. 
　　9. Shu, H.B., Halpins, D.R. and Goeddel, D.V. (1997). Casper is a FADD and Caspase-related Inducer of Apoptosis. Immunity 6, 751-763.
　　10. Shu, H.B. (1997). Early events of TNF signaling pathways, In Apoptosis: practical applications and novel therapeutics. IBC's Library Series. International Business Communications, Inc.
　　11. Yeh, W.C., Pompa, J.L., McCurrach, M.E., Shu, H.B., Elia, A.J., Shahinian, A., Ng, M., Wajegam, A., Mithchell, K., El-Deiry, W.S., Lowe, S.W., Goeddel, D.V. and Mak, T.W. (1998). FADD: essential for embryonic development and signaling from some, but not all, inducers of apoptosis. Science 279, 1954-1958.
　　12. Shu, H.B.*, Hu, W.H., Johnson, H. (1999). TALL-1 is a novel member of the TNF family that is downregulated by mitogens. J. Leukocyte Biology 65:680-683.
　　13. Hu, W.H., Johnson, H., Shu, H.B.* (1999). TRAIL signal NF-kB and JNK activation and apoptosis through distinct pathways. J. Biol. Chem. 274:30603-30610.
　　14. Hu, W.H., Johnson, H., Shu, H.B. * (2000). Activation of NF-kB by FADD, Casper and Caspase-8. J. Biol. Chem. 275:10838-10844.
　　15. Shu, H.B.*, Johnson, H. (2000). BCMA is a receptor for the TNF family member TALL-1. Proc. Natl. Acad. Sci. USA. 97:9156-9161.
　　16. Yeh, W.C., Itie, A., Elia, A.J., Ng, M., Shu, H.B., Wakeham, A., Mirtsos, C., Suzuki, N., Bonnard, M., Goeddel, D.V., and Mak, T.W. (2000). Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development. Immunity 12:633-642.
　　17. Xia, H., Xu L.G., Li X., Zhai Z., and Shu, H.B.* (2001). CSN3 interacts with IKKg and inhibits TNF- but not IL-1induced NF-kB activation. FEBS Letter 499:133-136.
　　18. Li, L., Hu, J., Bin, L., Li, L., Xu, L., Zha, J., Zhai, Z., and Shu, H.B.* (2001). Recombinant soluble TRAIL induces apoptosis of cancer cells. Chinese Science Bulletin 46:
　　19. Li, L., and Shu, H.B.* (2001). Molecular mechanisms of TRAIL-induced apoptosis. Chinese Science Bulletin 46:617-619. (review).
　　20. Zha, J., and Shu, H.B.* (2002). Signaling by tumor necrosis factor. Sciences in China. (review)
　　21. Zhou, J., Shu, H.B., and Joshi, H.C. (2002). Regulation of tubulin synthesis and cell cycle progression in mammalian cells by g-tubulin-mediated microtubule nucleation. J. Cellular Biochemistry 9999:1-12.
　　22. Bin, L., Li, X., Shu, H.B.* (2002). The short splice form of Casper/c-FLIP is a major inhibitor of TRAIL-induced apoptosis. FEBS Letter, 510:37-40.
　　23. Chen, D., Li, X., Zhai, Z., and Shu, H.B.* (2002). A novel zinc finger protein interacts with RIP and inhibits TNF- and IL-1-induced NF-kB activation. J. Biol. Chem. 277:15985-15991.
　　24. Liu, Y., Xu, L., Opalka, N., Kappler, J., Shu, H.B., and Zhang, G. (2002). Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands. Cell 108: 383-394.
　　25. Wu, M., Xu, L., Li, X., Zhai, Z. and Shu, H.B.* (2002). AMID, an AIF homologous mitochondrion-associated protein, induces caspase-independent apoptosis. J. Biol. Chem. 277:25617-25623.
　　26. Xu, L., Wu, M., Zhai, Z and Shu, H.B.* (2002). Identification of genes regulated by the tumor necrosis factor family member TALL-1. J. Leukocyte Biology, 72:410-416.
　　27. Xu, L., and Shu, H.B.* (2002). TRAF3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kB activation and IL10 production. J. Immunol. 169: 6883-6889.
　　28. Liu, Y., Hong, X., Kappler, J., Jiang, L., Zhang, R., Xu, L, Pan, C.H, Martin, W. E., Murphy, R. C., Shu, H.B., Dai, S., and Zhang, G. (2003). Ligand-receptor binding revealed by the TNF family member TALL-1. Nature 423:49-56.
　　29. Chen, D., Xu, L.G., Chen, L., Li, L., Zhai, Z., and Shu, H.B.* (2003). NIK is a component of the EGF/Heregulin receptor signaling complex. Oncogene, 22:4348-4355.
　　30. Wu, M., Xu, L., Zhai, Z., and Shu, H.B.* (2003). SINK: a p65-interacting protein that negatively regulates NF-kB-dependent transcription. J. Biol. Chem., 278:27072-27079.
　　31. Bin, L., Xu, L., Shu, H.B.* (2003). TIRP: a novel TIR domain-containing adapter protein involved in toll/interleukin-1 receptor signaling. J. Biol. Chem., 27:24526-24532.
　　32. Bin, L., Nielson, L. D., Liu, X., Mason R. J., Shu, H. B.* (2003). Identification of UGRP1 and MARCO as a lung-specific ligand-receptor pair. J. Immunol. 171:924-930.
　　33. Li, Z., Zhang, J., Chen, D., Shu, H.B.* (2003). Casper/c-FLIP is physically and functionally associated with NF-kB1 p105. 309:980-985.
　　34. Chen, D., Li, Z., Yang, Q., Zhang, J., Zhai, Z., Shu, H.B.* (2003). Identification of a nuclear protein that promotes NF-kappaB activation. Biochem Biophys Res Commun. 310:720-724.
　　35. Huang, J., Teng, L., Liu, T., Li, L., Chen, D., Li, F., Xu, L.G., Zhai, Z., Shu, H.B.* (2003). Identification of a novel serine/threonine kinase that inhibits TNF-induced NF-kappaB activation and p53-induced transcription. Biochem Biophys Res Commun. 309:774-778.
　　36. Zhang, J., Xu, L.G., Han, K.J., Shu, H.B.* (2004). Identification of a ZU5 and death domain containing inhibitor of NF-kB. J Biol Chem. 279:17819-17825.
　　37. Zhang, J., Xu, L.G., Han, K.J., Wei, X., Shu, H.B.* (2004). PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis. FEBS Lett. 570:97-101. 
　　38. Zha, J., Zhou, Q, Xu, L.G., Chen, D., Li, L., Zhai, Z., Shu, H.B.* (2004). RIP5 is a RIP-homologous inducer of cell death. Biochem. Biophys. Res. Commun. 319:298-303.
　　39. Lesley, R., Xu, Y., Kalled, S.L., Hess, D.M., Schwab, S.R., Shu, H.B., Cyster, J.G. (2004). Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF.Immunity 20:441-453. 
　　40. Han, K.J., Su, X., Xu, L.G., Bin, L.H., Zhang, J., Shu, H.B.* (2004). Mechanisms of TRIF-induced ISRE and NF-kappa B activation and apoptosis pathways. J. Biol. Chem. 279:15652-15661.
　　41. Xu. L.G., Li. L.Y., Shu, H.B.* (2004). TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis. J. Biol. Chem. 279:17278-17282.
　　42. Huang, J., Teng, L., Li, L., Liu, T., Li, L., Chen, D., Xu, L.G., Zhai, Z., Shu, H.B.* (2004). ZNF216 is an A20-like and IKKgamma -interacting inhibitor of NF-kappa B activation. J. Biol Chem. 279:16847-16853.
　　43. Wang, Y.Y., Li, L., Han, K.J., Zhai, Z., Shu, H.B.* (2004). A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter. FEBS Lett. 576:86-90. 
　　44. Wu, M., Xu, L.G., Su, T., Tian, Y., Zhai, Z., Shu, H.B.* (2004). AMID is a p53-inducible gene downregulated in tumors. Oncogene 23:6815681-9. 
　　45. Li, L., Bin, L., Li, F., Liu, Y., Chen, D., Zhai, Z., Shu, H.B.* (2004). TRIP6 is a RIP2-associated common signaling component of multiple NF-kB activation pathways. J. Cell Science 118: 555-563

（本页最后更新时间：2006年2月20日）